Returning to a semblance of normalcy in this country
will require the ability to gauge a person’s immunity status to the COVID-19
virus using serology tests—that is, blood tests that detect antibody levels.
People who were infected by the virus and recovered
generated a durable immune response by developing antibodies to antigens
specific to the virus.
That is to say, the body’s immune system creates molecules called antibodies that are designed to target and attack certain unique features of the virus called antigens.
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People who have developed the antibodies to the virus are able to fight it off if the virus enters their bodies again, so those with the antibody are unlikely to be reinfected with the virus and unlikely to be able to transmit the virus to anyone else.
In this way, knowing the immune status of the population
will be important to assessing the risk of the community returning to work.
Furthermore, being able to detect an individual’s immune status will also help public health researchers and officials determine the virus’ penetrance, the extent to which it has infected the population.
This is possible because certain antibodies persist in
the blood long after the infection, even if an individual never showed any
symptoms from the virus.
The ability to detect previous asymptomatic infections
will be important because recent evidence suggests that a potentially large
proportion of infected people never show symptoms.
Universal COVID-19 screening on hospital labor and delivery wards in New York City found that, of the women who tested positive for the virus, 29 out of 33 were asymptomatic at diagnosis. Of those 29 women, 26 of them remained asymptomatic, while only three developed fevers.
For each woman who tested positive for COVID-19 and
showed symptoms, there were more than seven other women who tested positive,
but did not show symptoms.
All 33 of them, even after they have recovered, will be
positive for antibodies if tested.
The above study is small, and being in New York City,
the study will oversample people who are infected, but it does strongly suggest
that the prevalence of the virus is much greater than the number of confirmed
cases in America would lead us to believe.
With antibody tests, we will have a better idea of this
The Food and Drug Administration recently granted an emergency use authorization to several new tests to detect antibodies in the blood.
This is part of the administration’s effort to move
rapidly in response to the pandemic, but there’s one important caveat to using
these tests: Because they have emergency authorizations rather than actual
approvals, the sensitivity data and positive predictive values are not
A test’s sensitivity is a measure of its ability to
detect what it’s intended to detect. If the test turns out to be relatively
insensitive, it will miss a large portion of people who have the antibody
present in their blood and suggest that they are still susceptible to the
Conversely, a test’s positive predictive value is a
measure of how truly positive a positive result is. With a low positive
predictive value, a test would be more likely to give a false positive, which
is a positive result despite absent antibodies.
Such a result would give someone false confidence of
their immunity, and this person could potentially become infected and become
the point of a new resurgence in the disease.
However, it’s likely that these tests will be more reliable than not. The three emergency use authorizations recently granted by the FDA were to Mount Sinai Laboratory, Chembio Diagnostic System, and Ortho Clinical Diagnostics, all of which either conduct or produce millions of tests or produce test equipment every year.
According to these authorizations, the FDA found that it is “reasonable to believe that [their] product may be effective in diagnosing COVID-19, and that the known and potential benefits of [their] product when used for diagnosing COVID-19 outweigh the known and potential risks.”
How these tests will be employed will be left up to the
states and localities, but they are a key “gating” feature of the White House’s
to reopen America, particularly for higher-risk individuals.
To monitor the activity of the virus, the states will
need to actively use both kinds of tests—the antibody tests and the current
polymerase chain reaction tests, or PCR tests, that amplify viral nucleic acid.
That’s because PCR tests detect viral RNA, which is present in an active infection. Thus, PCR is needed for current cases of COVID-19. The body generates an antibody response later in the disease course, so the serology tests will not be positive for days or weeks after the onset of symptoms, depending on what kind of antibodies are being tested for.
The presence of antibodies confers immunity to the virus, but it will still be absolutely necessary to continue practicing good hygiene and exercise caution.
Immunity to the COVID-19 virus is not invincibility, and there is some question about how long the immunity will last or how complete it is.
Current evidence suggests that the virus’ genetic code is relatively stable so it should not evade our immune system each year the way influenza does, but as it is a new virus, there is still much that scientists and clinicians do not know.
For most people, antibodies should confer protection from the virus. With more antibody testing, we can learn more about our immune response to the virus. It will give us a better idea of who can return to work and when.
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